Prefect: H.Em. Card. José Tolentino de Mendonça

Secretary: H.E. Msgr. Paul Desmond Tighe (Culture Section)

Secretary: H.E. Msgr. Giovanni Cesare Pagazzi (Education Section)

Under-Secretary: Fr. Antonino Spadaro, S.J.

Under-Secretary: Msgr. Matthias Ambros
 

Adjunct Under-Secretary: Msgr. Carlo Maria Polvani